Structure-Function Correlation of Juxtapapillary Choroidal Thickness With Visual Field Analysis of Patients Suspected With Glaucoma
Maria Katrina L. Malgapu, Celeste P. Guzman
May 2020 DOI 10.35460/2546-1621.2018-0125 Access
Purpose: To conduct an evaluation of juxtapapillary choroidal thickness of patients suspected with glaucoma obtained through spectral domain optical coherence tomography (SD-OCT) and correlate it with perimetry results.
Methods Design: Cross-sectional Study Population: 175 eyes diagnosed as “glaucoma suspect” had standard automated perimetry (SAP) to document the presence of functional glaucomatous damage using optimal near-point correction using the Humphrey Visual Field Analyzer II, 30-2 or 24-2 SITA-standard program. SD-OCT imaging of the retinal nerve fiber layer (RNFL) was also done to look for structural glaucomatous damage and in using enhanced depth imaging of the optic nerve and the Cirrus caliper tool, choroidal thickness was measured at five predetermined points temporal and nasal from the optic nerve. The population was classified into two groups: Group 1 are those with structural or functional glaucomatous damage (n=68) and Group 2 were those without (n=107).
Results: One-Way Multivariate Analysis of Covariance was used in comparing the mean temporal and nasal choroidal thickness scores of the two groups. There are no statistical differences in terms of the mean temporal choroidal thickness (p=0.856) and mean nasal choroidal thickness (p=0.734) between patients with and without glaucomatous damage. The mean temporal and nasal choroidal thickness scores of the two groups at different juxtapapillary locations: 0 μm, 250 μm, 500 μm, 750 μm and 1000 μm away from the disc were also not statistically different.
Conclusion: Results show that from this present cohort of glaucoma suspect patients, juxtapapillary choroidal thickness is not correlated with structural and functional glaucomatous damage.
Keywords: juxtapapillary choroidal thickness, glaucoma suspect, standard automated perimetry, spectral domain optical coherence tomography, enhanced depth imaging, retinal nerve fiber layer
- Chang RT, Singh K. Glaucoma suspect: Diagnosis and management. Asia Pac J Ophthalmol (Phila). 2016;5(1):32–7.
- Sullivan-Mee M, Patel NB, Pensyl D, Qualls C. Relationship between juxtapapillary choroidal volume and beta-zone parapapillary atrophy in eyes with and without primary open-angle glaucoma. Am J Ophthalmol. 2015;160(4):637-47 e1.
- Sigler EJ, Mascarenhas KG, Tsai JC, Loewen NA. Clinicopathologic correlation of disc and peripapillary region using SD-OCT. Optom Vis Sci. 2013;90(1):84–9.
- Wang S, Wang Y, Gao X, Qian N, Zhuo Y. Choroidal thickness and high myopia: a cross-sectional study and meta-analysis. BMC Ophthalmol. 2015;15:70.
- Elze T, Pasquale LR, Shen LQ, Chen TC, Wiggs JL, Bex PJ. Patterns of functional vision loss in glaucoma determined with archetypal analysis. J R Soc Interface. 2015;12(103).
- Manjunath V, Taha M, Fujimoto JG, Duker JS. Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography. Am J Ophthalmol. 2010;150(3):325–9 e1.
- Zhang X, Loewen N, Tan O, Greenfield DS, Schuman JS, Varma R, et al. Predicting development of glaucomatous visual field conversion using baseline fourier-domain optical coherence tomography. Am J Ophthalmol. 2016;163:29–3.
- Medeiros FA, Weinreb RN, Sample PA, Gomi CF, Bowd C, Crowston JG, et al. Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma. Arch Ophthalmol. 2005;123(10):1351–60.
- Hayreh SS. Blood supply of the optic nerve head and its role in optic atrophy, glaucoma, and oedema of the optic disc. Br J Ophthalmol. 1969;53(11):721–48.
- Spraul CW, Lang GE, Lang GK, Grossniklaus HE. Morphometric changes of the choriocapillaris and the choroidal vasculature in eyes with advanced glaucomatous changes. Vision Res. 2002;42(7):923–32.
- Schuman JS. Spectral domain optical coherence tomography for glaucoma (an AOS thesis). Trans Am Ophthalmol Soc. 2008;106:426–58.
- Lee KM, Lee EJ, Kim TW. Juxtapapillary choroid is thinner in normal-tension glaucoma than in healthy eyes. Acta Ophthalmol. 2016;94(8):e697–e708.
- Lee SH, Lee EJ, Kim TW. Topographic correlation between juxtapapillary choroidal thickness and microstructure of parapapillary atrophy. Ophthalmology. 2016;123(9):1965–73.
- Sacconi R, Deotto N, Merz T, Morbio R, Casati S, Marchini G. SD-OCT choroidal thickness in advanced primary open-angle glaucoma. J Glaucoma. 2017;26(6):523–7.
- Roberts KF, Artes PH, O'Leary N, Reis AS, Sharpe GP, Hutchison DM, et al. Peripapillary choroidal thickness in healthy controls and patients with focal, diffuse, and sclerotic glaucomatous optic disc damage. Arch Ophthalmol. 2012;130(8):980–6.
- Ehrlich JR, Peterson J, Parlitsis G, Kay KY, Kiss S, Radcliffe NM. Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography. Exp Eye Res. 2011;92(3):189–94.
- Bartz-Schmidt KU, Thumann G, Jonescu-Cuypers CP, Krieglstein GK. Quantitative morphologic and functional evaluation of the optic nerve head in chronic open-angle glaucoma. Surv Ophthalmol. 1999;44(Suppl 1):S41–53.
- Akil H, Al-Sheikh M, Falavarjani KG, Francis B, Chopra V. Choroidal thickness and structural glaucoma parameters in glaucomatous, preperimetric glaucomatous, and healthy eyes using swept-source OCT. Eur J Ophthalmol. 2017;27(5):548–54.
- Lundberg K, Vergmann AS, Vestergaard AH, Jacobsen N, Goldschmidt E, Peto T, et al. A comparison of two methods to measure choroidal thickness by enhanced depth imaging optical coherence tomography. Acta Ophthalmol. 2019;97(1):118-20.
- Yarmohammadi A, Zangwill LM, Diniz-Filho A, Suh MH, Manalastas PI, Fatehee N, et al. Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes. Invest Ophthalmol Vis Sci. 2016;57(9):Oct451–9.
Articles related to the one you are viewing
There are currently no results to show, please try again later
CC BY: Open Access Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/